Description
Buy PNC-27 5mg
🧬 PNC-27 5mg Lyophilized Peptide (p53-Derived Chimeric Peptide)
Product Overview
Quality Research Chemicals offers premium-grade PNC-27 5mg in ultra-pure, lyophilized vial formats synthesized exclusively for in-vitro laboratory testing and analytical research applications. As an investigational, membrane-active chimeric peptide, PNC-27 features an HDM-2 binding domain derived from residues 12–26 of the p53 tumor-suppressor protein, combined with a cell-penetrating transmembrane leader sequence.
This specialized structure allows researchers to investigate mechanisms involving selective cell membrane interaction, mitochondrial membrane disruption, and localized osmotic pressure changes. Every batch undergoes rigorous quality-assurance protocols to guarantee verifiable identity and standard-setting purity levels.
🔬 Technical Specifications & Chemical Profile
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- Compound Name: PNC-27
- Alternative Names: p53(12-26)-MRP peptide, HDM-2 Binding Peptide
- Active Concentration: 5mg per vial
- Sequence Structure: H-Pro-Pro-Leu-Ser-Gln-Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn-Gln-Phe-Trp-Val-Lys-Val-Gln-Arg-Gly-OH
- Physical Form: Lyophilized (freeze-dried) sterile white powder
- Purity Level: ≥99% verified via HPLC / Mass Spectrometry
- Molecular Weight: 4031.73 g/mol
- Format: Airtight, vacuum-sealed clear glass vials with rubber stoppers and protective flip-off caps
🧪 Primary Research Applications
PNC-27 5mg vials are manufactured to facilitate advanced multi-disciplinary research, including:
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- Selective Membranolysis Studies: Examining how the peptide complex co-localizes with membrane-expressed HDM-2 to induce transmembrane pore formation.
- Cell Necrosis Kinetics: Analyzing paths of rapid cell implosion resulting from shifting osmotic pressures across compromised membranes without triggering apoptosis.
- Mitochondrial Disruption: Investigating the inner entry mechanisms where the peptide binds to and destabilizes mitochondrial lipid bilayers.
- Cell Specificity Mapping: Studying comparative cytolytic pathways between transformed abnormal cell lines and healthy, untransformed control fibroblasts.
📦 Storage, Stability, and Reconstitution Guidelines
To preserve the structural integrity of the peptide bonds and prevent degradation:
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- Lyophilized Powder Storage: Store the dry powder at -20°C for up to 12 months. For multi-year archives, maintain storage conditions at -80°C away from moisture and light.
- Reconstitution Process: Allow the vial to come to room temperature before inserting any liquid vector. Reconstitute slowly using sterile bacteriostatic water or sterile saline. Swirl gently in a circular motion; do not shake the vial, as vigorous agitation can fracture the delicate peptide chain.
- Post-Reconstitution Care: Once dissolved, aliquot the liquid into single-test volumes and freeze immediately at -20°C or lower. Avoid recurrent freeze-thaw cycles, which accelerate baseline molecular decay.
⚠️ Laboratory Safety Disclaimer
THIS PRODUCT IS INTENDED SOLELY AS A LABORATORY RESEARCH CHEMICAL.
PNC-27 5mg distributed by Quality Research Chemicals is strictly synthesized for in-vitro laboratory experimentation, analytical testing, and scientific evaluation. This compound is NOT for human consumption, clinical therapy, diagnostics, cosmetics, or veterinary administration. All handling must be conducted by certified professionals wearing proper personal protective equipment (PPE) inside a controlled laboratory setting.
PNC-27 5mg distributed by Quality Research Chemicals is strictly synthesized for in-vitro laboratory experimentation, analytical testing, and scientific evaluation. This compound is NOT for human consumption, clinical therapy, diagnostics, cosmetics, or veterinary administration. All handling must be conducted by certified professionals wearing proper personal protective equipment (PPE) inside a controlled laboratory setting.
🔒 The Quality Research Chemicals Advantage
- Analytical Verification: Full third-party HPLC & Mass Spec documentation available for security audits upon request.
- Optimal Stability: Lyophilized under vacuum to guarantee exact dosing precision and zero baseline environmental degradation.
- Expedited Handling: Processed through secure, domestic shipping nodes utilizing temperature-controlled monitoring protocols.
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